POZZO
Good. Is everybody ready? Is everybody looking at me? (He looks at Lucky, jerks the rope. Lucky raises his head.) Will you look at me, pig! (Lucky looks at him.) Good. (He puts the pipe in his pocket, takes out a little vaporizer and sprays his throat, puts back the vaporizer in his pocket, clears his throat, spits, takes out the vaporizer again, sprays his throat again, puts back the vaporizer in his pocket.) I am ready. Is everybody listening? Is everybody ready? (He looks at them all in turn, jerks the rope.) Hog! (Lucky raises his head.) I don't like talking in a vacuum. Good. Let me see.
He reflects. (1.426)
Pozzo is arguably the loneliest character in Waiting for Godot. While he makes a big show out of interacting with others and praising the benefits of human connection, he is always focused on himself, not on others. When he says "I don’t like talking in a vacuum," it’s clear that his concern is with his own ego, not in whether others hear or benefit from what he is saying.
POZZO
I do. But instead of driving him away as I might have done, I mean instead of simply kicking him out on his arse, in the goodness of my heart I am bringing him to the fair, where I hope to get a good price for him. The truth is you can't drive such creatures away. The best thing would be to kill them.
Lucky weeps. (1.450)
This brings us back to the earlier exchange in which Vladimir and Estragon debate killing themselves. It became clear then that isolation was a worse fate than death, and Pozzo reiterates that here. Lucky’s response—weeping—is unclear. Does he weep at the thought of being driven away? Or of being killed? Or is he simply distraught that Pozzo no longer wants his company?
POZZO
Make haste, before he stops. (Estragon approaches Lucky and makes to wipe his eyes. Lucky kicks him violently in the shins. Estragon drops the handkerchief, recoils, staggers about the stage howling with pain.) (1.454)
This is a perfect example of the way isolation works in Waiting for Godot. One man makes an attempt to connect to another, and the second man violently pushes him away.