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Thank you We sneak in Molecular genetics Dangerous mutations shmoop

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so a lot of mutations or bad hemophilia Tay sachs

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cancer Ric you're an expert in how does that work

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Meaning I remember reading about sickle cell anemia existed in

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africa because it fought malaria very well And it let

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you live to about twenty five years old to just

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reproduce And then it would kill you like and so

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some of these things you understand genetically why they exist

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because it let the person replicate But then they passed

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on the bad gene Why do we have bad mutations

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You know that's a great question Why do mutations even

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persist if they're so detrimental in some cases there's Some

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benefit that we might not know that for example sickle

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cell people have one copy One bad copy The genius

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resistant to malaria too Bad copies You're gonna get sickle

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cell anemia In other cases musicians just happened for no

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reason And they're bad It's Not like a weren't selected

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for but you happen to get them through bad luck

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And so you have a disease That was it How

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do we get deadly mutations How does that work Is

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it just kind of a crap shoot in the way

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We were of all yes mutations can arise in a

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couple of ways One is that there are some rice

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which is then time net replicant today And it just

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makes mistakes sometimes it's pretty good but sometimes their mistakes

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that don't get fixed And why does it make a

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mistake Like what would be the cause Or is it

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just there's so many of them Eventually you're gonna have

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someone transcribed the number wrong Yeah i think both of

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those are right So sometimes yeah it has to replicate

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you know billions of nucleotides every time a cell divides

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Also there are certain places where it tends to slip

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So let's say there's a bunch of teas in a

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row it's possible the sunrise We'll lose track and not

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realize what it where it is A kind of slipped

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back and re duplicate that so there's certain hot spots

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of mutations But then also they're totally random at times

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But you could also get mutations externally So from the

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sun we know that you be could damage your skin

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computations tobacco smoke vacation so it can kind of be

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internal or external And the how you cope with that

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I mean certainly different people cope differently But certain mutations

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are going to just one hundred percent cause certain diseases

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So for example if you have a taste expedition you're

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gonna get yeah Why do we have bad mutations How 00:02:30.42 --> [endTime] do we get deadly mutations

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